Checksum-based filter exploits the fact that the messages are sent in bulk, that is that they will be identical with small variations. Checksum-based filters strip out everything that might vary between messages, reduce what remains to a checksum, and look that checksum up in a database which collects the checksums of messages that email recipients consider to be spam (some people have a button on their email client which they can click to nominate a message as being spam); if the checksum is in the database, the message is likely to be spam.
The advantage of this type of filtering is that it lets ordinary users help identify spam, and not just administrators, thus vastly increasing the pool of spam fighters. The disadvantage is that spammers can insert unique invisible gibberish—known as hashbusters—into the middle of each of their messages, thus making each message unique and having a different checksum. This leads to an arms race between the developers of the checksum software and the developers of the spam-generating software.
